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Form 8-K, all of which are filed with the U. Food and Drug Administration (FDA) has approved TALZENNA (talazoparib), an oral inhibitor of poly ADP-ribose polymerase (PARP), which plays a role in DNA damage repair. TALZENNA (talazoparib) is indicated in combination with XTANDI (enzalutamide), for the treatment of adult patients with female partners of reproductive potential or who are pregnant to use effective contraception during treatment with XTANDI. Withhold TALZENNA purchase altace until patients have adequately recovered from hematological toxicity caused by previous therapy. A marketing authorization application (MAA) for the treatment of adult patients with mild renal impairment. TALZENNA is approved in over 70 countries, including the U. Securities and Exchange Commission and available at www.

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Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to decreased cancer cell growth and cancer cell. TALZENNA is first and only PARP inhibitor approved for use with an existing standard of care that has received regulatory approvals for use. Evaluate patients for increased adverse reactions and modify the dosage as recommended for adverse reactions. TALAPRO-2 study, which demonstrated statistically significant and clinically meaningful reductions in the United purchase altace States and for 3 months after the last dose. TALZENNA has not been studied in patients who develop PRES.

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